Dextran CLIO Magnetic Nanoparticles - Streptavidin, Fluorescent Dye

General Information
Fluorescent, Streptavidin functionalized Dextran coated crosslinked iron oxide nanoparticles (CLIO-STRP-D) have 1-3 superparamagnetic Fe3O4 iron oxide cores (8-10 nm in diameter) imbedded within the matrix of dextran strands of 40 or 70 kDa in size. Dextran strands are crosslinked to prevent their disassociation, ensuring long-term stability. Streptavidin and fluorescence dye are covalently conjugated to the nanoparticle surface.
 
Features
Superparamagnetic
Fluorescently labeled (AFDye 488, AFDye 555, AFDye 647, or IR750 dye)
Highly biocompatible, non-toxic
Long term stable under physiological conditions
40 kDa and 70 kDa dextran coats are available
Easy loading of biomolecules such as Antibodies through Streptavidin-Biotin interaction
 
Applications
 
In vitro and in vivo dual magnetic and fluorescence labels for cells and tissues.
Magnetic, fluorescence, or dual cell separation.
Probes for MRI.
 
Specifications
Fluorescent Dye:
AFDye 488 (AlexaFluor 488 analog, Abs/Em = 490/525, Filter set: FITC)
AFDye 555 (AlexaFluor 555 analog, Abs/Em = 555/580, Filter set: TRITC)
AFDye 647 (AlexaFluor 647 analog, Abs/Em = 650/665, Filter set: Cy5)
IR750 (IRDye 750 analog, Abs/Em = 756/776, Filter set: Cy7)
Iron Oxide Core Diameter: 8 – 10 nm
Hydrodynamic Diameter: 70 – 130 nm
Polydispersity Index (PDI): < 0.3
Magnetization:  5 – 30 emu/g (room temperature)
Shelf life: > 1 year (4°C storage)
Supplied as liquid suspension in sterile PBS
 
Citations:
Gu, Huan, et al. "Magnetically driven active topography for long-term biofilm control." Nature communications 11.1 (2020): 1-11.