PLGA Nanoparticles, Magnetic, Fluorescently Labeled
Description
Our single-layer poly (lactic-co-glycolic acid) (PLGA) nanoparticles form nanostructures with a hydrophobic core encapsulated inside a hydrophilic shell. Dye molecules and magnetic nanoparticles are encapsulated inside the hydrophobic core. PLGA surface contains COOH groups that can be used for EDC/NHS based bioconjugation. Optional surface modifications include methoxy PEG (improves in vivo blood half-life) and PEG-Azide (can be used to covalently attach biomolecules by click chemistry)
Features
- Made with FDA approved biocompatible and biodegradable PLGA polymer.
- Conjugation-ready for covalent attachment of biomolecules.
- High degree of monodispersity.
- Can be pulled down by application of magnetic force.
- Labeled with a fluorescent dye.
- (Optional) Incorporation of Methoxy-PEG minimizes non-specific protein adsorption. This increase nanoparticle in-vivo blood half-life.
- (Optional) Incorporation of Azide-PEG allows conjugation of proteins and small molecules by click chemistry.
Applications
- Dual labeled fluorescence and magnetic nanoparticles for in-vivo tar-geting.
- Dual fluorescence and MRI imaging for in vitro and in vivo applications.
- Dual labeled fluorescence and magnetic probes for magnetic cell pull-down and flowcytometry analysis.
- In vitro and in vivo delivery of proteins and small molecules.
Product is supplied as lyophilized powder.